Abstract EPAC1, a cAMP-activated GEF for Rap GTPases, is a major transducer of cAMP signaling and a therapeutic target in cardiac diseases.The recent discovery that cAMP is compartmentalized in membrane-proximal nanodomains challenged the current model of EPAC1 activation in the cytosol.Here, we Baggies discover that anionic membranes are a major c
The research of the architecture of churches in villages of the Armenians of the Lower Don (Myasnikovsky district of the Rostov region of the Russian Federation) was conducted in threadheaders.shop order to identify their urban, historical and aesthetic value and significance in the history of the Armenian Diaspora.The analysis of the stylistic fea
Continuation of antihypertensives preoperatively and their influence on intraoperative hemodynamics is Leather a big concern among anesthesiologists.The Peri Operative Ischaemia Study Evaluation (POISE) trial showed a significant reduction of myocardial infarction, need for coronary revascularization and the incidence of atrial fibrillation with me
Background: The impact of long-term exposure to nitrogen dioxide (NO2) on cause-specific mortality is poorly understood.Objective: To assess mortality risks associated with long-term NO2 exposure and evaluate confounding of this association.Methods: We examined the association between 12-month moving average NO2 exposure and cause-specific mortalit